International Journal of Biomedical Science and Engineering

Submit a Manuscript

Publishing with us to make your research visible to the widest possible audience.

Propose a Special Issue

Building a community of authors and readers to discuss the latest research and develop new ideas.

Assessment of Nasal Mucosal Healing with Different Nasal Packing Techniques: A Study of 100 Patients

Introduction: Nasal packing is frequently utilized for bleeding control and healing promotion after nasal procedures. However, it can also cause damage to the nasal mucosa and slow the recovery process. This investigation aims to evaluate nasal mucosal healing in 100 patients with various nasal packing methods. Methods: A prospective study performed involving 100 participants who underwent nasal surgeries and were treated with diverse nasal packing approaches. Participants were split into four categories: no packing, saline-impregnated packing, antibiotic-impregnated packing, and hyaluronic acid-impregnated packing. Endoscopic assessment and mucosal healing scoring systems were used to evaluate nasal mucosal healing. Results: The study found that the hyaluronic acid-impregnated packing group had substantially better nasal mucosal healing along with reduced discomfort and pain than the other groups. The saline-impregnated and antibiotic-impregnated packing groups experienced less favorable healing outcomes. Conclusion: Hyaluronic acid-impregnated packing is a safe and effective nasal packing material that offers improved nasal mucosal healing outcomes along with decreased postoperative pain and discomfort.

Hyaluronic Acid, Saline Impregnation, Nasal Packing, Hemostatic, Septoplasty, Rhinoplasty, Sinus Surgery

APA Style

Kashiroygoud Biradar, Sanjay Kumar. (2023). Assessment of Nasal Mucosal Healing with Different Nasal Packing Techniques: A Study of 100 Patients. International Journal of Biomedical Science and Engineering, 11(2), 20-26. https://doi.org/10.11648/j.ijbse.20231102.11

ACS Style

Kashiroygoud Biradar; Sanjay Kumar. Assessment of Nasal Mucosal Healing with Different Nasal Packing Techniques: A Study of 100 Patients. Int. J. Biomed. Sci. Eng. 2023, 11(2), 20-26. doi: 10.11648/j.ijbse.20231102.11

AMA Style

Kashiroygoud Biradar, Sanjay Kumar. Assessment of Nasal Mucosal Healing with Different Nasal Packing Techniques: A Study of 100 Patients. Int J Biomed Sci Eng. 2023;11(2):20-26. doi: 10.11648/j.ijbse.20231102.11

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Weber RK. Nasal packing and stenting. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2009; 8: Doc02. doi: 10.3205/cto000054. Epub 2011 Mar 10. PMID: 22073095; PMCID: PMC3199821.
2. Karatas A, Pehlivanoglu F, Salviz M, Kuvat N, Cebi IT, Dikmen B, Sengoz G. The effects of the time of intranasal splinting on bacterial colonization, postoperative complications, and patient discomfort after septoplasty operations. Braz J Otorhinolaryngol. 2016 Nov-Dec; 82 (6): 654-661. doi: 10.1016/j.bjorl.2015.11.008. Epub 2016 Feb 6. PMID: 26923831; PMCID: PMC9444780.
3. Cayonu M, Acar A, Horasanlı E, Altundag A, Salihoglu M. Comparison of totally occlusive nasal pack, internal nasal splint, and transseptal suture technique after septoplasty in terms of immediate respiratory distress related to anesthesia and surgical complications. Acta Otolaryngol. 2014 Apr; 134 (4): 390-4. doi: 10.3109/00016489.2013.878476. Epub 2014 Feb 11. PMID: 24512461.
4. Chandra RK, Conley DB, Kern RC. The effect of FloSeal on mucosal healing after endoscopic sinus surgery: a comparison with thrombin-soaked gelatin foam. Am J Rhinol. 2003 Jan-Feb; 17 (1): 51-5. PMID: 12693656.
5. Özkırış M, Kapusuz Z, Saydam L. Comparison of nasal packs with transseptal suturing after nasal septal surgery. Am J Otolaryngol. 2013 Jul-Aug; 34 (4): 308-11. doi: 10.1016/j.amjoto.2012.12.012. Epub 2013 Feb 8. PMID: 23394817.
6. Rajapaksa SP, Cowin A, Adams D, Wormald PJ. The effect of a hyaluronic acid-based nasal pack on mucosal healing in a sheep model of sinusitis. Am J Rhinol. 2005 NovDec; 19 (6): 572-6. PMID: 16402643.
7. Cho KS, Shin SK, Lee JH, Kim JY, Koo SK, Kim YW, Kim MJ, Roh HJ. The efficacy of Cutanplast nasal packing after endoscopic sinus surgery: a prospective, randomized, controlled trial. Laryngoscope. 2013 Mar; 123 (3): 564-8. doi: 10.1002/lary.23643. Epub 2012 Oct 19. PMID: 23086679.
8. Kastl KG, Betz CS, Siedek V, Leunig A. Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery. Am J Rhinol Allergy. 2009 JanFeb; 23 (1): 80-4. doi: 10.2500/ajra.2009.23.3267. PMID: 19379618.
9. Acıoğlu E, Edizer DT, Yiğit Ö, Onur F, Alkan Z. Nasal septal packing: which one? Eur Arch Otorhinolaryngol. 2012 Jul; 269 (7): 1777-81. doi: 10.1007/s00405-011-1842-1. Epub 2011 Dec 9. PMID: 22160143.
10. Sikka, Monica & Midha, Vinay. (2018). The role of biopolymers and biodegradable polymeric dressings in managing chronic wounds. 10.1016/B978-0-08-102192-7.00016-3.
11. Zhang, Yingping & Wang, Yue & Chen, Lin & Zheng, Jun & Fan, Xiaojing & Xu, Xing-Lian & Zhou, G. H. & Ullah, Niamat. (2022). An injectable antibacterial chitosan-based cryogel with high absorbency and rapid shape recovery for noncompressible hemorrhage and wound healing. Biomaterials. 285. 121546. 10.1016/j.biomaterials.2022.121546.
12. Lund VJ, Kennedy DW. Quantification for staging sinusitis. The Staging and Therapy Group. Ann Otol Rhinol Laryngol Suppl. 1995 Oct; 167: 17-21. PMID: 7574265.
13. Gao Y, Sun Y, Yang H, Qiu P, Cong Z, Zou Y, Song L, Guo J, Anastassiades TP. A Low Molecular Weight Hyaluronic Acid Derivative Accelerates Excisional Wound Healing by Modulating Pro-Inflammation, Promoting Epithelialization and Neovascularization, and Remodeling Collagen. Int J Mol Sci. 2019 Jul 30; 20 (15): 3722. doi: 10.3390/ijms20153722. PMID: 31366051; PMCID: PMC6695899.
14. Hussain Z, Thu HE, Shuid AN, Katas H, Hussain F. Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art. Curr Drug Targets. 2018; 19 (5): 527-550. doi: 10.2174/1389450118666170704132523. PMID: 28676002.
15. Shi R, Zhou J, Wang B, Wu Q, Shen Y, Wang P, Wang J, Wang Y, Chen Y, Shu XZ. The clinical outcomes of new hyaluronan nasal dressing: a prospective, randomized, controlled study. Am J Rhinol Allergy. 2013 Jan; 27 (1): 71-6. doi: 10.2500/ajra.2013.27.3833. PMID: 23406605.
16. Zhang L, D'Amora U, Ronca A, Li Y, Mo X, Zhou F, Yuan M, Ambrosio L, Wu J, Raucci MG. In vitro and in vivo biocompatibility and inflammation response of methacrylated and maleated hyaluronic acid for wound healing. RSC Adv. 2020 Aug 28; 10 (53): 32183-32192. doi: 10.1039/d0ra06025a. PMID: 35518130; PMCID: PMC9056621.
17. Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med. 2009 Aug; 37 (8): 1636-44. doi: 10.1177/0363546508326984. Epub 2009 Jan 23. PMID: 19168804.
18. Gouteva I, Shah-Hosseini K, Meiser P. Clinical efficacy of a spray containing hyaluronic Acid and dexpanthenol after surgery in the nasal cavity (septoplasty, simple ethmoid sinus surgery, and turbinate surgery). J Allergy (Cairo). 2014; 2014: 635490. doi: 10.1155/2014/635490. Epub 2014 Jul 1. PMID: 25104962; PMCID: PMC4106138.
19. Schulz A, Germann A, Heinz WR, Engelhard M, Menz H, Rickmann A, Meiser I, Wien S, Wagner S, Januschowski K, Szurman P. Translation of hyaluronic acid-based vitreous substitutes towards current regulations for medical devices. Acta Ophthalmol. 2023 Jun; 101 (4): 422-432. doi: 10.1111/aos.15301. Epub 2022 Dec 1. PMID: 36457299.
20. Kogan G, Soltés L, Stern R, Gemeiner P. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007 Jan; 29 (1): 17-25. doi: 10.1007/s10529-006-9219-z. Epub 2006 Nov 8. PMID: 17091377.