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The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review

Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains limited, highlighting the urgent need for innovative strategies to improve patient outcomes. Ferroptosis is a unique type of cell death triggered by excessive iron levels. It sets itself apart from other forms of cell death, such as apoptosis and necrosis, characterized by an overabundance of lipid peroxides and reactive oxygen species. Ferroptosis plays a critical role in sustaining the viability of healthy cells and tissues. However, specific cancerous cells are vulnerable to this process. The resistance of pancreatic cancer cells to chemotherapeutic drugs has become the main reason for chemotherapy failure. Inducing ferroptosis in cancer cells is the best way to overcome chemotherapy resistance. Small molecule drugs can cause iron death through glutathione depletion and lipid peroxidation. Ferroptosis inhibitors may become an adjuvant therapy enhancer, acting with ferroptosis inducers on pancreatic tumor cells. As such, the induction of ferroptosis may offer a promising new avenue for cancer treatment. This article examines PC's iron-induced cell death regulatory mechanism and potential therapeutic applications.

Ferroptosis, Pancreatic Cancer (PC), Glutathione Peroxidase 4 (GPX4), System XC, Tumor Microenvironment (TME)

APA Style

Zhang, J., Zhao, Y. (2023). The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. International Journal of Biomedical Science and Engineering, 11(4), 54-60.

ACS Style

Zhang, J.; Zhao, Y. The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. Int. J. Biomed. Sci. Eng. 2023, 11(4), 54-60. doi: 10.11648/j.ijbse.20231104.12

AMA Style

Zhang J, Zhao Y. The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. Int J Biomed Sci Eng. 2023;11(4):54-60. doi: 10.11648/j.ijbse.20231104.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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