The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients

Wenming Shao; Zengxi Yao; Yabin Jiang

doi:doi:10.11648/j.ijbse.20210901.12

| Peer-Reviewed

The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients

Wenming Shao, Zengxi Yao, Yabin Jiang

Published in International Journal of Biomedical Science and Engineering (Volume 9, Issue 1)

Received: 23 December 2020 Accepted: 7 January 2021 Published: 25 January 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×10⁹/L vs. 227.13±75.97×10⁹/L, P<0.05). The results showed PLT count (HR: 0.993, 95% CI: 0.987-0.997, P=0.043), the area under the ROC curve of PLT count was 0.717, the best cut off was 179.5 × 10⁹ / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 10⁹ / L) and the low PLT count group (<179.5 × 10⁹ / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.

Published in	International Journal of Biomedical Science and Engineering (Volume 9, Issue 1)
DOI	10.11648/j.ijbse.20210901.12
Page(s)	6-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Platelet Count, Acute Aortic Dissection, Stanford Type B

References

[1]	Morris JH, Mix D. Cameron SJ Acute Aortic Syndromes: Update in Current Medical Management. Curr Treat Options Cardiovasc Med. 2017; 19 (4): 29.
[2]	Masuda Y, Yamada Z, Morooka N, Watanabe S, Inagaki Y. Prognosis of patients with medically treated aortic dissections. Circulation. 1991; 84 (5 Suppl): 7-13.
[3]	McCullough JN, Zhang N, Reich DL, Juvonen TS, Klein JJ, Spielvogel D et al. Cerebral metabolic suppression during hypothermic circulatory arrest in humans. Ann Thorac Surg. 1999; 67 (6): 1895-9; discussion 1919-21.
[4]	Tsai TT, Fattori R, Trimarchi S, TsIsselbacher E, Myrmel T, Evangelista A, et al. Long-term survival in patients presenting with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection. Circulation. 2006; 114 (21): 2226-31.
[5]	Tsai TT, Evangelista A, Nienaber CA, Trimarchi S, Sechtem U, Fattori R, et al. Long-term survival in patients presenting with type A acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation. 2006; 114 (1 Suppl): I350-6.
[6]	Wen D, Du X, Dong JZ, Zhou XL, Ma CS. Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection. Heart. 2013; 99 (16): 1192-7.
[7]	Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Llovet A, et al. Predicting death in patients with acute type a aortic dissection. Circulation. 2002; 105 (2): 200-6.
[8]	Mehta RH, O'Gara PT, Bossone E, Nienaber CA, Myrmel T, Cooper JV, et al. Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era. J Am Coll Cardiol. 2002; 40 (4): 685-92.
[9]	Sütsch G, Jenni R, von SL, Turina M, et al. Predictability of aortic dissection as a function of aortic diameter. Eur Heart J. 1991; 12 (12): 1247-56.
[10]	Suzuki T, Mehta RH, Ince H, Nagai R, Sakomura Y, Weber F, et al. Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Registry of Aortic Dissection (IRAD) [J]. Circulation, 2003; 108 Suppl 1: II312-7.
[11]	Li Y, Yang N, Duan W, Liu S, Liu S, Yu S, Yi D. Acute aortic dissection in China. Am J Cardiol. 2012; 110 (7): 1056-61.
[12]	Huang B, Tian L, Fan X, Zhu J, Liang Y, Yang Y. Low admission platelet counts predicts increased risk of in-hospital mortality in patients with type A acute aortic dissection. Int J Cardiol. 2014; 172 (3): e484-6.
[13]	Qin, C., Zhang, H., Gu, J. et al. Dynamic monitoring of platelet activation and its role in post-dissection inflammation in a canine model of acute type A aortic dissection. J Cardiothorac Surg. 2016; 86: 11.
[14]	Tanaka M, Kawahito K, Adachi H, Ino T. Platelet dysfunction in acute type A aortic dissection evaluated by the laser light-scattering method. J Thorac Cardiovasc Surg. 2003; 126 (3): 837-41.
[15]	Morello F, Cavalot G, Giachino F, Tizzani M, Nazerian P, Carbone F, et al. White blood cell and platelet count as adjuncts to standard clinical evaluation for risk assessment in patients at low probability of acute aortic syndrome. Eur Heart J Acute Cardiovasc Care. 2017; 6 (5): 389-395.
[16]	Sbarouni E, Georgiadou P, Analitis A, Voudris V. Significant changes in platelet count, volume and size in acute aortic dissection. Int J Cardiol. 2013; 168 (4): 4349-50.
[17]	Onuk T, Güngör B, Karataş B, Ipek G, Akyüz S, Ozcan KS, et al. Increased Neutrophil to Lymphocyte Ratio is Associated with In-Hospital Mortality in Patients with Aortic Dissection. Clin Lab. 2015; 61 (9): 1275-82.
[18]	Oz K, Iyigun T, Karaman Z, Çelik Ö, Akbay E, Akınc O, et al. Prognostic Value of Neutrophil to Lymphocyte Ratio and Risk Factors for Mortality in Patients with Stanford Type A Aortic Dissection. Heart Surg Forum. 2017; 20 (3): E119-E123.
[19]	Spirito R, Pompilio G, Alamanni F, Agrifoglio M, Dainese L, Parolari A, et al. A preoperative index of mortality for patients undergoing surgery of type A aortic dissection. J Cardiovasc Surg (Torino). 2001; 42 (4): 517-24.
[20]	Rampoldi V, Trimarchi S, Eagle KA, Nienaber CA, Oh JK, Bossone E, et al. Simple risk models to predict surgical mortality in acute type A aortic dissection: the International Registry of Acute Aortic Dissection score. Ann Thorac Surg. 2007; 83 (1): 55-61.

Cite This Article

Plain Text BibTeX RIS

APA Style

Wenming Shao, Zengxi Yao, Yabin Jiang. (2021). The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. International Journal of Biomedical Science and Engineering, 9(1), 6-10. https://doi.org/10.11648/j.ijbse.20210901.12

Copy | Download

ACS Style

Wenming Shao; Zengxi Yao; Yabin Jiang. The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. Int. J. Biomed. Sci. Eng. 2021, 9(1), 6-10. doi: 10.11648/j.ijbse.20210901.12

Copy | Download

AMA Style

Wenming Shao, Zengxi Yao, Yabin Jiang. The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. Int J Biomed Sci Eng. 2021;9(1):6-10. doi: 10.11648/j.ijbse.20210901.12

Copy | Download

@article{10.11648/j.ijbse.20210901.12,
  author = {Wenming Shao and Zengxi Yao and Yabin Jiang},
  title = {The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {9},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ijbse.20210901.12},
  url = {https://doi.org/10.11648/j.ijbse.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20210901.12},
  abstract = {Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×109/L vs. 227.13±75.97×109/L, P9 / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 109 / L) and the low PLT count group (9 / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients
AU  - Wenming Shao
AU  - Zengxi Yao
AU  - Yabin Jiang
Y1  - 2021/01/25
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbse.20210901.12
DO  - 10.11648/j.ijbse.20210901.12
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20210901.12
AB  - Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×109/L vs. 227.13±75.97×109/L, P9 / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 109 / L) and the low PLT count group (9 / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.
VL  - 9
IS  - 1
ER  -

Copy | Download

Author Information

Wenming Shao

Department Emergency, The First Affiliated Hospital of Jinan University, Guangzhou, China
Zengxi Yao

Department Emergency, The First Affiliated Hospital of Jinan University, Guangzhou, China
Yabin Jiang

Department Emergency, The First Affiliated Hospital of Jinan University, Guangzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Wenming Shao, Zengxi Yao, Yabin Jiang. (2021). The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. International Journal of Biomedical Science and Engineering, 9(1), 6-10. https://doi.org/10.11648/j.ijbse.20210901.12

Copy | Download

ACS Style

Wenming Shao; Zengxi Yao; Yabin Jiang. The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. Int. J. Biomed. Sci. Eng. 2021, 9(1), 6-10. doi: 10.11648/j.ijbse.20210901.12

Copy | Download

AMA Style

Wenming Shao, Zengxi Yao, Yabin Jiang. The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients. Int J Biomed Sci Eng. 2021;9(1):6-10. doi: 10.11648/j.ijbse.20210901.12

Copy | Download

@article{10.11648/j.ijbse.20210901.12,
  author = {Wenming Shao and Zengxi Yao and Yabin Jiang},
  title = {The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {9},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ijbse.20210901.12},
  url = {https://doi.org/10.11648/j.ijbse.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20210901.12},
  abstract = {Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×109/L vs. 227.13±75.97×109/L, P9 / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 109 / L) and the low PLT count group (9 / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients
AU  - Wenming Shao
AU  - Zengxi Yao
AU  - Yabin Jiang
Y1  - 2021/01/25
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbse.20210901.12
DO  - 10.11648/j.ijbse.20210901.12
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20210901.12
AB  - Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×109/L vs. 227.13±75.97×109/L, P9 / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 109 / L) and the low PLT count group (9 / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.
VL  - 9
IS  - 1
ER  -

Copy | Download