Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures

Abdelsamie Halawa; Ahmed Mohamed Morsi; Ahmed Kamel Hassan; Waleed Mohamed Fathy Moussa

doi:doi:10.11648/j.ijbse.20210904.13

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Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures

Abdelsamie Halawa, Ahmed Mohamed Morsi, Ahmed Kamel Hassan, Waleed Mohamed Fathy Moussa

Published in International Journal of Biomedical Science and Engineering (Volume 9, Issue 4)

Received: 11 October 2021 Accepted: 29 November 2021 Published: 11 December 2021

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Abstract

Background: During the last decades, our understanding of fracture healing has evolved rapidly. Bone can heal without forming a fibrous scar and, as such, the process of fracture healing recapitulates bone development and may be considered a form of tissue regeneration. The cell and tissue proliferation and differentiation processes involved in fracture healing are regulated by growth factors, inflammatory cytokines, antioxidants, hormones, amino acids, and other nutrients. Objective: To identify changes in serum level of calcium, ionized calcium, alkaline phosphatase and parathyroid hormone according to mode of trauma (low and high energy) in forearm fractures. Patients and Methods: 50 Patients with forearm fracture were prospectively recruited from the emergency department within 48 hours of sustaining the fracture. Patients included in the study were asked to avoid calcium supplementation during fracture healing. Results: Mean PTH was elevated in both groups at Day 1 with low energy group was insignificantly higher than high energy group, whereas after 8 weeks mean PTH level decreased in both groups but in low energy group mean PTH level was significantly higher than high energy group. Mean ALP level increased in both groups at Day 1 whereas in low energy group it was insignificantly higher than that of high energy group, After 8 weeks mean ALP level insignificantly decreased to normal level in both groups. Mean serum calcium level was below normal level in both groups where it was insignificantly higher in high energy group than that of low energy group which increased after 8 weeks in both groups but remained insignificantly elevated in high energy than low energy group. Mean serum ionized calcium level was below normal level at Day 1 in both groups whereas it was insignificantly higher in high energy group than low energy group which after 8 weeks increased in both groups but remained insignificantly elevated in high energy group than low energy group. Conclusion: Serial monitoring of these markers reflect the actual status of bone resorption, and bone formation respectively over a short period. Thus, they can be used as an adjunct to clinical and radiological evidence of fracture healing.

Published in	International Journal of Biomedical Science and Engineering (Volume 9, Issue 4)
DOI	10.11648/j.ijbse.20210904.13
Page(s)	89-95
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Alkaline Phosphatase, Parathyroid Hormone, Forearm Fracture, Biological Markers

References

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APA Style

Abdelsamie Halawa, Ahmed Mohamed Morsi, Ahmed Kamel Hassan, Waleed Mohamed Fathy Moussa. (2021). Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. International Journal of Biomedical Science and Engineering, 9(4), 89-95. https://doi.org/10.11648/j.ijbse.20210904.13

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ACS Style

Abdelsamie Halawa; Ahmed Mohamed Morsi; Ahmed Kamel Hassan; Waleed Mohamed Fathy Moussa. Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. Int. J. Biomed. Sci. Eng. 2021, 9(4), 89-95. doi: 10.11648/j.ijbse.20210904.13

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AMA Style

Abdelsamie Halawa, Ahmed Mohamed Morsi, Ahmed Kamel Hassan, Waleed Mohamed Fathy Moussa. Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. Int J Biomed Sci Eng. 2021;9(4):89-95. doi: 10.11648/j.ijbse.20210904.13

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@article{10.11648/j.ijbse.20210904.13,
  author = {Abdelsamie Halawa and Ahmed Mohamed Morsi and Ahmed Kamel Hassan and Waleed Mohamed Fathy Moussa},
  title = {Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {9},
  number = {4},
  pages = {89-95},
  doi = {10.11648/j.ijbse.20210904.13},
  url = {https://doi.org/10.11648/j.ijbse.20210904.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20210904.13},
  abstract = {Background: During the last decades, our understanding of fracture healing has evolved rapidly. Bone can heal without forming a fibrous scar and, as such, the process of fracture healing recapitulates bone development and may be considered a form of tissue regeneration. The cell and tissue proliferation and differentiation processes involved in fracture healing are regulated by growth factors, inflammatory cytokines, antioxidants, hormones, amino acids, and other nutrients. Objective: To identify changes in serum level of calcium, ionized calcium, alkaline phosphatase and parathyroid hormone according to mode of trauma (low and high energy) in forearm fractures. Patients and Methods: 50 Patients with forearm fracture were prospectively recruited from the emergency department within 48 hours of sustaining the fracture. Patients included in the study were asked to avoid calcium supplementation during fracture healing. Results: Mean PTH was elevated in both groups at Day 1 with low energy group was insignificantly higher than high energy group, whereas after 8 weeks mean PTH level decreased in both groups but in low energy group mean PTH level was significantly higher than high energy group. Mean ALP level increased in both groups at Day 1 whereas in low energy group it was insignificantly higher than that of high energy group, After 8 weeks mean ALP level insignificantly decreased to normal level in both groups. Mean serum calcium level was below normal level in both groups where it was insignificantly higher in high energy group than that of low energy group which increased after 8 weeks in both groups but remained insignificantly elevated in high energy than low energy group. Mean serum ionized calcium level was below normal level at Day 1 in both groups whereas it was insignificantly higher in high energy group than low energy group which after 8 weeks increased in both groups but remained insignificantly elevated in high energy group than low energy group. Conclusion: Serial monitoring of these markers reflect the actual status of bone resorption, and bone formation respectively over a short period. Thus, they can be used as an adjunct to clinical and radiological evidence of fracture healing.},
 year = {2021}
}

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TY  - JOUR
T1  - Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures
AU  - Abdelsamie Halawa
AU  - Ahmed Mohamed Morsi
AU  - Ahmed Kamel Hassan
AU  - Waleed Mohamed Fathy Moussa
Y1  - 2021/12/11
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbse.20210904.13
DO  - 10.11648/j.ijbse.20210904.13
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 89
EP  - 95
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20210904.13
AB  - Background: During the last decades, our understanding of fracture healing has evolved rapidly. Bone can heal without forming a fibrous scar and, as such, the process of fracture healing recapitulates bone development and may be considered a form of tissue regeneration. The cell and tissue proliferation and differentiation processes involved in fracture healing are regulated by growth factors, inflammatory cytokines, antioxidants, hormones, amino acids, and other nutrients. Objective: To identify changes in serum level of calcium, ionized calcium, alkaline phosphatase and parathyroid hormone according to mode of trauma (low and high energy) in forearm fractures. Patients and Methods: 50 Patients with forearm fracture were prospectively recruited from the emergency department within 48 hours of sustaining the fracture. Patients included in the study were asked to avoid calcium supplementation during fracture healing. Results: Mean PTH was elevated in both groups at Day 1 with low energy group was insignificantly higher than high energy group, whereas after 8 weeks mean PTH level decreased in both groups but in low energy group mean PTH level was significantly higher than high energy group. Mean ALP level increased in both groups at Day 1 whereas in low energy group it was insignificantly higher than that of high energy group, After 8 weeks mean ALP level insignificantly decreased to normal level in both groups. Mean serum calcium level was below normal level in both groups where it was insignificantly higher in high energy group than that of low energy group which increased after 8 weeks in both groups but remained insignificantly elevated in high energy than low energy group. Mean serum ionized calcium level was below normal level at Day 1 in both groups whereas it was insignificantly higher in high energy group than low energy group which after 8 weeks increased in both groups but remained insignificantly elevated in high energy group than low energy group. Conclusion: Serial monitoring of these markers reflect the actual status of bone resorption, and bone formation respectively over a short period. Thus, they can be used as an adjunct to clinical and radiological evidence of fracture healing.
VL  - 9
IS  - 4
ER  -

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Author Information

Abdelsamie Halawa

Ortthopedic Department, Benha University, Benha, Egypt
Ahmed Mohamed Morsi

Orthopedic Department, Ain Shams University, Cairo, Egypt
Ahmed Kamel Hassan

Orthopedic Department, Ain Shams University, Cairo, Egypt
Waleed Mohamed Fathy Moussa

Ortthopedic Department, Benha University, Benha, Egypt

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APA Style

Abdelsamie Halawa, Ahmed Mohamed Morsi, Ahmed Kamel Hassan, Waleed Mohamed Fathy Moussa. (2021). Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. International Journal of Biomedical Science and Engineering, 9(4), 89-95. https://doi.org/10.11648/j.ijbse.20210904.13

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ACS Style

Abdelsamie Halawa; Ahmed Mohamed Morsi; Ahmed Kamel Hassan; Waleed Mohamed Fathy Moussa. Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. Int. J. Biomed. Sci. Eng. 2021, 9(4), 89-95. doi: 10.11648/j.ijbse.20210904.13

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AMA Style

Abdelsamie Halawa, Ahmed Mohamed Morsi, Ahmed Kamel Hassan, Waleed Mohamed Fathy Moussa. Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures. Int J Biomed Sci Eng. 2021;9(4):89-95. doi: 10.11648/j.ijbse.20210904.13

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@article{10.11648/j.ijbse.20210904.13,
  author = {Abdelsamie Halawa and Ahmed Mohamed Morsi and Ahmed Kamel Hassan and Waleed Mohamed Fathy Moussa},
  title = {Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {9},
  number = {4},
  pages = {89-95},
  doi = {10.11648/j.ijbse.20210904.13},
  url = {https://doi.org/10.11648/j.ijbse.20210904.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20210904.13},
  abstract = {Background: During the last decades, our understanding of fracture healing has evolved rapidly. Bone can heal without forming a fibrous scar and, as such, the process of fracture healing recapitulates bone development and may be considered a form of tissue regeneration. The cell and tissue proliferation and differentiation processes involved in fracture healing are regulated by growth factors, inflammatory cytokines, antioxidants, hormones, amino acids, and other nutrients. Objective: To identify changes in serum level of calcium, ionized calcium, alkaline phosphatase and parathyroid hormone according to mode of trauma (low and high energy) in forearm fractures. Patients and Methods: 50 Patients with forearm fracture were prospectively recruited from the emergency department within 48 hours of sustaining the fracture. Patients included in the study were asked to avoid calcium supplementation during fracture healing. Results: Mean PTH was elevated in both groups at Day 1 with low energy group was insignificantly higher than high energy group, whereas after 8 weeks mean PTH level decreased in both groups but in low energy group mean PTH level was significantly higher than high energy group. Mean ALP level increased in both groups at Day 1 whereas in low energy group it was insignificantly higher than that of high energy group, After 8 weeks mean ALP level insignificantly decreased to normal level in both groups. Mean serum calcium level was below normal level in both groups where it was insignificantly higher in high energy group than that of low energy group which increased after 8 weeks in both groups but remained insignificantly elevated in high energy than low energy group. Mean serum ionized calcium level was below normal level at Day 1 in both groups whereas it was insignificantly higher in high energy group than low energy group which after 8 weeks increased in both groups but remained insignificantly elevated in high energy group than low energy group. Conclusion: Serial monitoring of these markers reflect the actual status of bone resorption, and bone formation respectively over a short period. Thus, they can be used as an adjunct to clinical and radiological evidence of fracture healing.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Serum Level of Parathyroid Hormone, Alkaline Phosphatase, Calcium and Ionized Calcium After Forearm Fractures
AU  - Abdelsamie Halawa
AU  - Ahmed Mohamed Morsi
AU  - Ahmed Kamel Hassan
AU  - Waleed Mohamed Fathy Moussa
Y1  - 2021/12/11
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbse.20210904.13
DO  - 10.11648/j.ijbse.20210904.13
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 89
EP  - 95
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20210904.13
AB  - Background: During the last decades, our understanding of fracture healing has evolved rapidly. Bone can heal without forming a fibrous scar and, as such, the process of fracture healing recapitulates bone development and may be considered a form of tissue regeneration. The cell and tissue proliferation and differentiation processes involved in fracture healing are regulated by growth factors, inflammatory cytokines, antioxidants, hormones, amino acids, and other nutrients. Objective: To identify changes in serum level of calcium, ionized calcium, alkaline phosphatase and parathyroid hormone according to mode of trauma (low and high energy) in forearm fractures. Patients and Methods: 50 Patients with forearm fracture were prospectively recruited from the emergency department within 48 hours of sustaining the fracture. Patients included in the study were asked to avoid calcium supplementation during fracture healing. Results: Mean PTH was elevated in both groups at Day 1 with low energy group was insignificantly higher than high energy group, whereas after 8 weeks mean PTH level decreased in both groups but in low energy group mean PTH level was significantly higher than high energy group. Mean ALP level increased in both groups at Day 1 whereas in low energy group it was insignificantly higher than that of high energy group, After 8 weeks mean ALP level insignificantly decreased to normal level in both groups. Mean serum calcium level was below normal level in both groups where it was insignificantly higher in high energy group than that of low energy group which increased after 8 weeks in both groups but remained insignificantly elevated in high energy than low energy group. Mean serum ionized calcium level was below normal level at Day 1 in both groups whereas it was insignificantly higher in high energy group than low energy group which after 8 weeks increased in both groups but remained insignificantly elevated in high energy group than low energy group. Conclusion: Serial monitoring of these markers reflect the actual status of bone resorption, and bone formation respectively over a short period. Thus, they can be used as an adjunct to clinical and radiological evidence of fracture healing.
VL  - 9
IS  - 4
ER  -

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