Research Article
Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice
Babatunde Oluwatoyin*,
Amuda Mutiu Olasunkanmi
,
Ore Ayokanmi
Issue:
Volume 12, Issue 1, March 2024
Pages:
1-9
Received:
29 January 2024
Accepted:
12 February 2024
Published:
2 April 2024
Abstract: This study investigated the potential of Persea americana stem bark for the treatment of inflammation and oxidation in mice. Oxidative stress occurs in the body when there is serious imbalance between the generation of free radicals and the antioxidant defense system, inflammation is a natural defense mechanism against pathogens and it is associated with many pathogenic diseases such as microbial and viral infections, exposure to allergens, radiation and toxic chemicals, autoimmune and chronic diseases, obesity, consumption of alcohol, tobacco use, and a high-calorie diet. Plants offer significant potentials for development of new anti-inflammatory therapies and treatment of diseases associated with inflammation and Oxidation. Stem bark of Persea ameriacna was extracted using EtOH/H2O (80:20 v/v), the extract obtained was subjected to maceration using 3 different solvents, hexane fraction (PAHF), Ethyl-acetate fraction (PAEF) and methanol fraction (PAMF). The methanol fraction came out with the highest yield and was used for the animal study, 30 male mice was divided into 3 different groups, LPS was introduced in one of the groups, PAMF was later administered to the same group, The experiment shows that the extract was able to demonstrate significant reduction in inflammation and also ameliorate oxidation in mice. In conclusion the methanolic fraction of Persea americana stem bark might contain beneficial phytochemicals that can be explored as potential anti-inflammatory and oxidative therapy.
Abstract: This study investigated the potential of Persea americana stem bark for the treatment of inflammation and oxidation in mice. Oxidative stress occurs in the body when there is serious imbalance between the generation of free radicals and the antioxidant defense system, inflammation is a natural defense mechanism against pathogens and it is associate...
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Research Article
Genetic Variability Analysis for Yield and Yield-Associated Traits of Finger Millet [Eleusine coracana (L.) Gaertn.] Accessions at Mechara, Eastern Ethiopia
Ababa Chimdi*,
Bulti Tesso,
Chemeda Daba
Issue:
Volume 12, Issue 1, March 2024
Pages:
10-18
Received:
13 April 2024
Accepted:
14 May 2024
Published:
6 June 2024
Abstract: The genetic enhancement of any crop, including finger millet, requires a certain degree of genetic variation for effective utilization in crop improvement programs. However, in Ethiopia, there is limited information on the extent and pattern of genetic variability of finger millet collections under diversified agro-climatic conditions. This makes it difficult for a population to adapt to changing environmental conditions. As a result, the population may be more vulnerable to extinction, exposure to new diseases, low productivity, and selection acting on any genes that may provide disease resistance. Therefore, knowledge of genetic variability is crucial for breeders in order to develop new cultivars with desired traits that are beneficial for both farmers and breeders. The present investigation was carried out to estimating the genetic variability, heritability, and genetic advance in sixty four finger millet accessions for yield and yield-related traits at Mechara agricultural research center. The experimental design was laid out in 8 x 8 simple lattice design. The analysis of variance for mean sum of squares due to genotypes revealed highly significant differences for all the 17 quantitative characters. The genotypes showed the highest mean performance for grain yield ranged from 1.38 ton per hectare for ACC#208448 to 4.35 ton per hectare for ACC#230255. Whereas, genotypic and phenotypic coefficients of variation were found high for biomass yield, harvest index, and grain yield. Broad-sense heritability ranged from 50.12% for the number of fingers per ear to 93.18% for days to heading. High heritability coupled with high genetic advance as percent of mean were observed for leaf number, finger length, ear weight, thousand grain weight, biomass yield, and harvest index. In general, the results demonstrated that the finger millet accessions exhibited a high degree of genetic variability for the traits studied, which can be helpful for genetic enhancement.
Abstract: The genetic enhancement of any crop, including finger millet, requires a certain degree of genetic variation for effective utilization in crop improvement programs. However, in Ethiopia, there is limited information on the extent and pattern of genetic variability of finger millet collections under diversified agro-climatic conditions. This makes i...
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