Research Article
Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis
Sara Harrar*,
Abderrahim Raissi,
Ayoub Bouchehboun,
Ibtissam Mhirig,
Saliha Chellak,
Abderrahman Boukhira
Issue:
Volume 11, Issue 4, December 2023
Pages:
50-53
Received:
1 June 2023
Accepted:
28 June 2023
Published:
28 October 2023
Abstract: Breast carcinoma is a tumor that tends to metastasize to various organs. The hasty diagnosis of metastasis in patients treated for breast carcinoma who report symptoms for another malignant tumor, may be the cause of diagnostic and therapeutic delay. We report the case of a patient with breast ductal carcinoma, having completed her therapeutic protocol, she came in 3 years later with severe bone pain, epistaxis and headache in a context of asthenia and anorexia, suggesting a relapse of her breast cancer with bone metastasis. On clinical examination, the patient presented with cutaneous and mucosal pallor. She had no other signs of secondary localization, the performance of electrophoresis and immunofixation of serum proteins, led to a diagnosis of multiple myeloma. This observation highlights the diagnostic difficulty that can arise in patients treated for breast carcinoma who present with a malignant hemopathy mimicking a metastasis of the initial cancer, or other cases where the multiple myeloma is synchronous with other malignancies. This clinical similarity may delay treatment and worsen the patient's condition. This situation can be avoided by the simple performance of protein electrophoresis, which is a relevant method of diagnosis and follow-up of monoclonal gammopathies thanks to the efficient separation of serum proteins and quantification of monoclonal peaks.
Abstract: Breast carcinoma is a tumor that tends to metastasize to various organs. The hasty diagnosis of metastasis in patients treated for breast carcinoma who report symptoms for another malignant tumor, may be the cause of diagnostic and therapeutic delay. We report the case of a patient with breast ductal carcinoma, having completed her therapeutic prot...
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Research Article
The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review
Jingchang Zhang,
Yongfu Zhao*
Issue:
Volume 11, Issue 4, December 2023
Pages:
54-60
Received:
10 November 2023
Accepted:
5 December 2023
Published:
6 December 2023
Abstract: Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains limited, highlighting the urgent need for innovative strategies to improve patient outcomes. Ferroptosis is a unique type of cell death triggered by excessive iron levels. It sets itself apart from other forms of cell death, such as apoptosis and necrosis, characterized by an overabundance of lipid peroxides and reactive oxygen species. Ferroptosis plays a critical role in sustaining the viability of healthy cells and tissues. However, specific cancerous cells are vulnerable to this process. The resistance of pancreatic cancer cells to chemotherapeutic drugs has become the main reason for chemotherapy failure. Inducing ferroptosis in cancer cells is the best way to overcome chemotherapy resistance. Small molecule drugs can cause iron death through glutathione depletion and lipid peroxidation. Ferroptosis inhibitors may become an adjuvant therapy enhancer, acting with ferroptosis inducers on pancreatic tumor cells. As such, the induction of ferroptosis may offer a promising new avenue for cancer treatment. This article examines PC's iron-induced cell death regulatory mechanism and potential therapeutic applications.
Abstract: Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains l...
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