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Based on Artificial Intelligence Neural Network CNN Method Analysis and Processing of Dynamic Optical Breast Lesion Images
Issue:
Volume 10, Issue 2, June 2022
Pages:
38-43
Received:
5 February 2022
Accepted:
26 February 2022
Published:
9 April 2022
Abstract: Breast cancer is the most common cancer in women. At present, the methods of examining lesions are generally mammography, or B-scanning and other methods with certain radioactive sources, which may lead to aggravation of breast lesions in young women. The dynamic optical breast scanning method uses infrared light to avoid the harm of X-rays to the human body. According to current research, doctors can use Dynamic Optical Breast Image (DOBI) to determine whether a patient has breast cancer. Studies have shown that convolutional neural networks (CNN) have higher detection accuracy in determining whether a patient has breast cancer. In this paper, we use an artificial intelligence neural network approach to analyze and process dynamic optical breast lesion images: we model the clinical lesion breast images in 3D, and use the VoxelMorph algorithm to segment the 3D images into 2D images; The time, space, location, and pathological trend curves in the image are analyzed and processed. We compared classification, sensitivity, and specific characteristics with the original dynamic breast lesion image scoring analysis system. The experimental results show that the accuracy is improved. At the same time, the problem of the original system's signature in the ROI area and leaf curve is solved. The use of CNN improves the analysis and processing speed, shortens the processing time, and increases the accuracy of the diagnostic reference from 83% to 90%.
Abstract: Breast cancer is the most common cancer in women. At present, the methods of examining lesions are generally mammography, or B-scanning and other methods with certain radioactive sources, which may lead to aggravation of breast lesions in young women. The dynamic optical breast scanning method uses infrared light to avoid the harm of X-rays to the ...
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A Brief Narrative Review of Glucose 6-phosphate Dehydrogenase Deficiency in Children and Its Genetic Variants
Yatika Chaudhary,
Rahul Bhakat,
Swathi Chacham,
Swati Rajput,
Prashant Kumar Verma,
Kriti Mohan,
Manisha Naithani
Issue:
Volume 10, Issue 2, June 2022
Pages:
44-49
Received:
28 March 2022
Accepted:
19 April 2022
Published:
10 May 2022
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most frequent enzyme deficiency which leading to substantial morbidity and mortality in children. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme present in cytoplasm, coded by X-linked gene. G6PD catalyzes the initial step in hexose monophosphate shunt, which is a rate limiting reaction. This shunt helps in producing NADPH (Nicotinamide adenine dinucleotide phosphate), a reducing equivalent that helps glutathione reductase to regenerate reduced glutathione (GSH). Due to its crucial role in defence against oxidizing species, it is perceived that any mutation in G6PD encoding gene can affect enzyme’s structural and functional integrity leading to malfunctioning of enzyme. G6PD deficiency is a highly prevalent genetic disorder which is transmitted as X–linked recessive pattern. Nearly 210 variants have been reported all over the world. In India, G6PD deficiency is a significant public health problem. It is an important cause for drug induced hemolysis in children. G6PD gene variants are often named as per the geographical area where they were first discovered. In India Mediterranean, Orissa, Jammu, Andhra Pradesh, Kalyan-Kerala and G6PD West Bengal are frequently seen. G6PD Mediterranean leads to severe deficiency when compared to others. Worldwide highest preponderance of g6PD deficiency is seen in African sub Saharan region and Arabian Peninsula.
Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most frequent enzyme deficiency which leading to substantial morbidity and mortality in children. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme present in cytoplasm, coded by X-linked gene. G6PD catalyzes the initial step in hexose monophosphate shunt, which is a rate limiting react...
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Femoral Nerve Anesthesia in Hostile Environments (Mountains)
Issue:
Volume 10, Issue 2, June 2022
Pages:
50-53
Received:
20 May 2022
Accepted:
6 June 2022
Published:
16 June 2022
Abstract: Traumatic injuries associated with adventure sports activities occur in hostile environment. The Femoral nerve anesthesia (FNA) outside of the hospital settings has been demonstrated but not in hostile environment. So, the objective of this study was to determine the feasibility of FNA for these very painful traumatized patients on the accident site and during their extraction-evacuation by helicoper. This prospective observational study was enrolled a convenience sample of 11 patients (4 women, 7 men) with closed fractures femurs. FNA was performed on all participants and 3 situations were defined (Impossible, Difficult if more than 1 attempt, Easy to perform). Pain evaluated using visual analog scale (VAS) (0-10) measured at the following time point: Rescue team arrival (T0), Ten minutes after FNA (T10), at Reduction of fracture (T Reduction) and during helicopter Evacuation (T Evacuation). The median age of the participants was aged 40 +/- 18 years. The accidents which occurred were 7 Skiing, 2 moutaineering, 1 snowshoeing, 1 parapliding. 11 FNA performed with 5 fascia iliaca blocks, 6 femoral nerve blocks. 82% blocks were technically easy and 18% difficult. Pain evaluation showed an average VAS of 7,5 (7-8) at T0, 1,1 (0-2) at T10, 0,45 (0-1) at T Reduction, 0,36 (0-1) at T Evacuation. All the pathologies were treated with reduction and immobilization. Helicopter evacuations were conducted without incident in a calm atmosphere and with excellent patient cooperation. In final, FNA performed in difficult environment is feasible, effective, and reproducible in extreme conditions. There is no limitation due to hostile terrain. FNA techniques used must simple and fast but performed by trained physicians who are technical experts in order achieve a successful outcome in difficult terrain.
Abstract: Traumatic injuries associated with adventure sports activities occur in hostile environment. The Femoral nerve anesthesia (FNA) outside of the hospital settings has been demonstrated but not in hostile environment. So, the objective of this study was to determine the feasibility of FNA for these very painful traumatized patients on the accident sit...
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Cellular Detection of Glutathione Using Synthesized Stable Sea Urchin-Like Gold Nanoparticles
Ting Lei Zhao,
Zhe Zhang,
Dan Li,
Yanxialei Jiang
Issue:
Volume 10, Issue 2, June 2022
Pages:
54-60
Received:
31 May 2022
Accepted:
15 June 2022
Published:
27 June 2022
Abstract: Gold nanoparticles (AuNPs) have been widely studied in a great mass of cellular biomarkers detection and diagnostics due to their unique combination of physical and optical properties. Sea urchin-like gold nanoparticles (SUL-AuNPs) are well characterized multi-thorn gold nanostructures which possess at least four gold nanothorns on spherical gold surface, mimicking the morphology of sea urchin. Compared to spherical AuNPs, SUL-AuNPs showed a wide variety of light absorption and scattering properties, and the Surface-enhanced Raman Scattering (SERS) properties of SUL-AuNPs were also widely studied dependent on their surface morphology. Herein, three different diameters of SUL-AuNPs based on spherical AuNPs seed-mediated growth method by altering the amount of AuNPs in reaction system had been synthesized. The UV-vis spectrum of synthesized SUL-AuNPs displayed a shift from 550 nm to 650 nm compared to spherical AuNPs. FRET method was applied for the detection of GSH in hepatocytes and cell extracts using rhodamine B (RB) functionalized SUL-AuNPs, among the synthesized three different diameters SUL-AuNPs, 100nm RB-SUL-AuNPs displayed highest sensitivity for GSH detection. What's more, all synthesized SUL-AuNPs turned out to be membrane-permeable, and displayed ignorable cytotoxicity, which make SUL-AuNPs promising cellular thiols detection probes. In particular, it should be noted that the application of RB functionalized SUL-AuNPs exemplify ongoing efforts in design and utility of multifunctional nanoplatforms of SUL-AuNPs.
Abstract: Gold nanoparticles (AuNPs) have been widely studied in a great mass of cellular biomarkers detection and diagnostics due to their unique combination of physical and optical properties. Sea urchin-like gold nanoparticles (SUL-AuNPs) are well characterized multi-thorn gold nanostructures which possess at least four gold nanothorns on spherical gold s...
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