Associations Between Inflammation Biomarkers and Serum Ferritin and Zinc Concentrations in Preschool Children in Nepal
Sanjay Rijal,
Sher Singh Dahit,
Dibya Laxmi Manandhar,
Sanjeev Kumar Sahani,
Kingsley Agho
Issue:
Volume 11, Issue 1, March 2023
Pages:
1-9
Received:
14 November 2022
Accepted:
26 December 2022
Published:
9 January 2023
Abstract: Concentration of trace nutrients is affected by inflammation; however, there has been limited research on iron and zinc, particularly in children. The objective of the current was to assess associations between inflammation biomarkers and serum ferritin and zinc concentrations., The study used α-1 glycoprotein (AGP) as a second biomarker because C-reactive protein (CRP) detection as a biomarker for inflammation is less sensitive in chronic infections The study utilized cross-sectional data of 1649 preschool Nepalese children from Nepal National Micronutrient Status Survey 2016. A standardized, highly sensitive technique was used to measure CRP and AGP. To obtain associations between CRP and AGP, nutrient concentrations were stratified across classifications of CRP and AGP. Concentrations level greater and smaller than several CRP and AGP cut-off points, namely, 0.5 mg/L, 1.0 mg/L, 3.0 mg/L and 5.0 mg/L (CRP) and 0.5 mg/L, 1.0 mg/L, 1.5 mg/L and 2.0 mg/L (AGP). With CRP biomarker at interval of > 0.5-1 mg/L, the median (25th and 75th percentiles) was 21.6 (11.5, 37.8) mg/L for ferritin; and 83.9 (63.8, 108.8) mg/L for zinc. Corresponding values for ferritin and zinc with AGP biomarker were 22.2 (10.9, 35.9) mg/L and 83.9 (65.6, 106.9) mg/L respectively. CRP concentration at interval of ≥ 5 mg/L was negatively associated with ferritin concentration [adjusted odds ratio (aOR)= 0.44, 95% confidence interval (CI): (0.24, 0.82)]. AGP concentration at interval of ≥ 1.0 mg/L was negatively associated with zinc concentration [aOR: 0.71; 95% CI: (0.50, 1.00)]. High CRP and AGP levels as defined by their low cut-off points (below0.5 mg/L) had no influence on zinc and ferritin concentrations. Using both CRP and AGP as biomarkers for inflammation provides higher precision in the detection of inflammation. This combination of biomarkers is therefore recommended in future research for assessing zinc and iron deficiencies. The negative association of CRP and AGP with serum ferritin and zinc concentrations highlight the need to pay special attention to non-biological factors with elevated levels of the two inflammation biomarkers.
Abstract: Concentration of trace nutrients is affected by inflammation; however, there has been limited research on iron and zinc, particularly in children. The objective of the current was to assess associations between inflammation biomarkers and serum ferritin and zinc concentrations., The study used α-1 glycoprotein (AGP) as a second biomarker because C-...
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Discuss the Risk of the Ventilator and Evaluate the Effect of Ozone Disinfection
Huang Xiaoping,
Mai Dacheng,
Chen Guanyuan,
Zhu Jianbo,
Xu Xuguang
Issue:
Volume 11, Issue 1, March 2023
Pages:
10-15
Received:
26 December 2022
Accepted:
26 January 2023
Published:
4 February 2023
Abstract: Objective: To understand the possibility of nosocomial risk in the internal pipeline of the ventilator, and to discuss the necessity of disinfection of the internal pipeline by comparing the total number of colonies in the experimental sampling pipeline. Methods: It is innovatively proposed to put the ventilator in a cubic confined space, and start the ventilator in the running state. For the first time, ozone gas is used for the ventilator to smoke the whole process of the ventilator, and design the prototype of the whole process of the ventilator pipeline disinfection machine. Results: by sampling the ventilator intake, outlet total colonies before disinfection and disinfection, with reference to health standards, test results show that the ventilator before disinfection internal management total colonies overweight phenomenon, the total number of bacterial colonies after disinfection detection results within the health standard, according to the statistical method analysis P value is 0, think the bacterial colonies before and after the ventilator disinfection have significant differences. Conclusion: The test result proves that the number of bacteria is lower than the standard value of 20, and the disinfection method has obvious effect. The internal pipe of the ventilator has the risk of hospital sensation. The disinfection method of ozone smoke is effective and safe, and the market needs the product of a ventilator.
Abstract: Objective: To understand the possibility of nosocomial risk in the internal pipeline of the ventilator, and to discuss the necessity of disinfection of the internal pipeline by comparing the total number of colonies in the experimental sampling pipeline. Methods: It is innovatively proposed to put the ventilator in a cubic confined space, and start...
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Evaluation Value of Brainstem Auditory Evoked Potentials in Rehabilitation of Children with Developmental Coordination Disorders
Yue Ling,
Wang Jing,
Li Xiaoli,
Bai Bing
Issue:
Volume 11, Issue 1, March 2023
Pages:
16-19
Received:
7 March 2023
Accepted:
10 April 2023
Published:
15 April 2023
Abstract: Objective: To investigate the effects of brainstem auditory evoked potentials (BAEP) in treatment of developmental coordination disorder (DCD) in children. Methods: A total of 87 high-risk children who was examined by brainstem auditory evoked potentials (BAEP) in our hospital from August 2017 to December 2018 were enrolled in the study. According to Peabody motor development scale, these patients were divided into developmental coordination disorder (DCD) group (n=54) and non-developmental coordination disorder (non-DCD) group (n=33). After 3-month comprehensive rehabilitation treatment, the latency and changes of BAEP were observed and compared between the two groups. Results: As compared with brainstem auditory evoked potentials (BAEP) in non-developmental coordination disorder (non-DCD) group, the III, V and I ~ III wave latencies in developmental coordination disorder (DCD) group were significantly prolonged (P<0.05). After comprehensive rehabilitation treatment, the latency of each wave of BAEP in developmental coordination disorder (DCD) group was significantly shortened (P<0.01), as compared with that before treatment and that in non-developmental coordination disorder (non-DCD) group (P>0.05). Conclusion: Brainstem auditory evoked potentials (BAEP) can comprehensively, objectively and sensitively reflect the conduction function of central nervous system in children with developmental coordination disorder (DCD), which has important clinical application value in the evaluation of early rehabilitation effects.
Abstract: Objective: To investigate the effects of brainstem auditory evoked potentials (BAEP) in treatment of developmental coordination disorder (DCD) in children. Methods: A total of 87 high-risk children who was examined by brainstem auditory evoked potentials (BAEP) in our hospital from August 2017 to December 2018 were enrolled in the study. According ...
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