Analysis of the Current Application of Peripheral Intravenous Catheter and Indwelling Failure in the Department of Hepatobiliary Surgery
Xiaolan Wang,
Mengying Qi,
Yanhua Shi,
Hualan Zhu,
Weirong Li,
Cuiqing Liu,
Jin’ai He
Issue:
Volume 8, Issue 4, December 2020
Pages:
44-50
Received:
4 August 2020
Accepted:
31 August 2020
Published:
7 October 2020
Abstract: Background: PIVC therapy is the most common hospital procedure. Its insertion and maintenance are easy to fail. Objective: To investigate the current application of peripheral venous catheter (PIVC) in the department of hepatobiliary surgery and the risk factors that lead to indwelling failure. Peripheral intravenous catheter therapy is one of the most common treatment procedures but has a relatively high failure rate during insertion and indwelling. Methods: A cross-sectional correlation study was adopted. Clinical data of patients receiving PIVC from March to June in 2019 in our hospital were collected. All patients were inserted with closed 24G IV catheters manufactured by BD Company, sealed with 50U/mL heparin saline and secured by 3M Tegaderm Film-Transparent film dressing. Estuation caused by any reasons within 72 hours that failed to complete the treatment was considered to be indwelling failure. Univariate analysis was performed to analyze the effect of gender and age on the indwelling time, and logistic regression was used to analyze the related factors of indwelling needle-induced complications. The methods were consistent with the STROBE criteria (Supplementary File 1). Results: 445 patients were enrolled and clinical data from 395 patients were analyzed eventually, with a total of 773 PIVC cases. The indwelling time varied from 0.5h to 329h (median time 49.00±0.86h). Indwelling site: back of the hand (61%), forearm (28%), joint (6%), upper arm (4%) and finger (1%). The success rate of one-time puncture was 92%. PIVC indwelling failure rate was 46% which appeared to be higher in females and older people. Complications included exudation (72%), phlebitis (8%), blockage (5%) and errhysis (4%). There were no statistically significant differences in the incidence of complications in each indwelling period (P>0.05). Logistic regression analysis showed that complications were independent risk factors for catheter indwelling failure (OR: 26.98, P<0.01). Conclusions: PIVC mostly performed on the back of the hand and its indwelling time was associated with patients’ gender and age in the department of hepatobiliary surgery. The occurrence of complications was an independent factor for PIVC failure.
Abstract: Background: PIVC therapy is the most common hospital procedure. Its insertion and maintenance are easy to fail. Objective: To investigate the current application of peripheral venous catheter (PIVC) in the department of hepatobiliary surgery and the risk factors that lead to indwelling failure. Peripheral intravenous catheter therapy is one of the ...
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The Effects of DNA Methylation on Medulloblastoma Cell Survivability and Development
Christina Rubino,
Anika Chowdhury,
Cassandra Greco,
Benjamin Honigsfeld,
Barbara Pepe,
Noelle Cutter
Issue:
Volume 8, Issue 4, December 2020
Pages:
51-57
Received:
11 November 2020
Accepted:
2 December 2020
Published:
11 December 2020
Abstract: Establish the role epigenetic methylation plays in the segregation of Medulloblastoma subgroups, through pathway analysis in the literature and cancer genome Atlas publicly available data. The goal is to develop an in-vitro assay to study therapeutic responses for subgroups 3 and 4. Functional analysis assays will be used to determine a mechanism for chemoresistance in specific subgroups. In the current study, we assessed Medulloblastoma group 3 (D341) and Group 4 (D283) cell lines using the DNA isolation kit and angiogenesis kits which allows for amplification via PCR and visualize tube formation for tumor nutrients. Twist 1 fended were measured and recorded with the methylation Gold. Group 3 MB cell lines treated with chemotherapy reagents demonstrate altered methylation profiles, angiogenic tube formation increase, a decrease in apoptosis, and underwent phenotypic changes to overcome resistance. Gel electrophoresis results indicated consistent Twist-1 expression in the DAOY+cisplatin cell line in comparison to the control. Cells treated with chemotherapeutic agents evade the mechanisms of apoptosis resulting in angiogenesis. We identified a possible correlation between cisplatin treatment, alteration of methylation patterns, and an increase of Twist-1 gene expression. Twist-1 previously identified to be involved in angiogenesis and cisplatin resistance (Roberts et al. 2016), this supports our hypothesis that alterations in methylation patterns result in an increase in overall chemoresistance.
Abstract: Establish the role epigenetic methylation plays in the segregation of Medulloblastoma subgroups, through pathway analysis in the literature and cancer genome Atlas publicly available data. The goal is to develop an in-vitro assay to study therapeutic responses for subgroups 3 and 4. Functional analysis assays will be used to determine a mechanism f...
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Mathematical Model of the Upper Limb Manual Lymph Drainage Massage
Carlos Gonçalves,
Alexandre Ferreira da Silva,
João Gomes,
Ricardo Simoes
Issue:
Volume 8, Issue 4, December 2020
Pages:
58-63
Received:
9 December 2020
Accepted:
16 December 2020
Published:
31 December 2020
Abstract: This paper reports the formulation of a mathematical model that describes the manual lymph drainage massage typically employed in the treatment of upper limb lymphedema. The ability to model such massage is a key feature for the development of automated physical therapy systems that aim at mimicking and assisting the therapist. This type of mathematical model can be hardcoded into a control system responsible to control a soft exoskeleton such as an upper limb sleeve. There is currently no similar model in the literature, nor is there information available about the actual forces exerted by the occupational therapists or the massage profile. Thus, this paper provides a deeper insight into the massage process, using the upper limb lymphedema as a case study. The first step of the design process was to identify the pressure amplitudes and profiles made by the occupational therapists during the manual lymph drainage. A commercial sensorized pressure glove was used to quantitatively analyze the massage. More than 50 occupational therapists wear the sensorized pressure glove when performing an upper limb drain massage and hours of pressure profiles were recorded. The loads and time spent at each compression were characterized, and the compression spots at the upper limb were identified. With the identification of the pressure sites, the respective load and the massage speed, we propose a model capable of mathematically describing the massage profile.
Abstract: This paper reports the formulation of a mathematical model that describes the manual lymph drainage massage typically employed in the treatment of upper limb lymphedema. The ability to model such massage is a key feature for the development of automated physical therapy systems that aim at mimicking and assisting the therapist. This type of mathema...
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