Research Article
Chemical Constituents, Antioxidant and Anti-inflammatory Properties of De-chlorophyllized Extracts of Salvia officinalis Leaf
Issue:
Volume 14, Issue 2, June 2026
Pages:
42-50
Received:
31 March 2026
Accepted:
15 April 2026
Published:
8 May 2026
Abstract: Background: Salvia officinalis is a medicinal plant used for the treatment of various disorders such as inflammation, rheumatism, ulcers, dizziness, high blood pressure and high blood sugar. Studies have associated its medicinal properties to its strong chemical constituents and various pharmacological effects. Objectives: The work was to evaluate the total contents of flavonoid, phenolic, saponins and tannin along with the antioxidant and anti-inflammatory properties of dechlorophyllized ethanol extract of Salvia officinalis leaf. Method: The Salvia officinalis leaves were macerated in ethanol and liquid-liquid extraction to obtain complete removal of the chlorophyll content. While the phytochemical constituents and the antioxidant, anti-inflammatory activities of dechlorophyllized extract of Salvia officinalis leaf were estimated by standard methods. Results: The flavonoid, phenolic, saponins and tannin contents of the Salvia officinalis dechlorophyllized leaves were 64.517mgQE/g, 91.433mgGAE/g, 185.666mgSE/g and 47.333mg/TAE/g extract respectively. The dechlorophylized extract had high antioxidant activity: ferric reducing antioxidant power (FRAP) of 14.157mg/l QE and IC50 of 16.28ppm with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. It had potent anti-inflammatory activity with IC50 value of 115.201ppm. Conclusion: The results demonstrated that Salvia officinalis leaf is a source of antioxidant and anti-inflammatory pharmacologic agents.
Abstract: Background: Salvia officinalis is a medicinal plant used for the treatment of various disorders such as inflammation, rheumatism, ulcers, dizziness, high blood pressure and high blood sugar. Studies have associated its medicinal properties to its strong chemical constituents and various pharmacological effects. Objectives: The work was to evaluate ...
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Research Article
Antimicrobial and Wound Healing Potentials of Methanol Extract of Salvia Officinalis (Common Sage) Leaf
Issue:
Volume 14, Issue 2, June 2026
Pages:
51-59
Received:
15 May 2026
Accepted:
1 June 2026
Published:
27 June 2026
DOI:
10.11648/j.ijbse.20261402.12
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Abstract: Background: Food-borne microbial infections continue to pose a significant public health burden, particularly in low-income nations, where they contribute substantially to morbidity and mortality. Their management is increasingly hampered by the spread of multidrug-resistant pathogens, hence the aim for the study. Methods: The study evaluated the antimicrobial and wound healing potentials of methanol extract of Salvia officinalis leaf (MESoL). Antimicrobial activity was assessed using the Mueller-Hinton agar well diffusion method against selected bacterial strains. Wound healing efficacy was investigated using an excision wound model in Wistar rats. Data were analyzed using one-way ANOVA with Dunnett's post hoc test. Results: MESoL and 1% silver sulfadiazine demonstrated sensitivity against Staphylococcus aureus, Corynebacterium ulcerans, Escherichia coli, Klebsiella pneumoniae, and Salmonella typhi. The minimum bactericidal concentration (MBC) values of MESoL for these organisms were 30mg/ml, 30mg/ml, 60mg/ml, 15mg/ml and 60mg/ml respectively. In vivo studies revealed a significant reduction in wound area (p < 0.05, p < 0.001) over 11 days compared to control groups. The extract promoted wound contraction and tissue repair, indicating both antimicrobial and healing potential. Conclusion: The methanol extract of Salvia officinalis leaf exhibits dual functions as a natural antimicrobial and wound-healing agent. These findings support its potential application as a complementary therapy for microbial infections and wound management.
Abstract: Background: Food-borne microbial infections continue to pose a significant public health burden, particularly in low-income nations, where they contribute substantially to morbidity and mortality. Their management is increasingly hampered by the spread of multidrug-resistant pathogens, hence the aim for the study. Methods: The study evaluated the a...
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,
Emeka Edward Okocha
